Stroke is the third leading cause of death in the United States and fifth leading cause of death worldwide1. Those who survive a stroke are often physically and/or mentally compromised for life.

1. Per WHO 2016 data



Sometimes called brain attacks, strokes occur when blood supply to part of the brain is blocked or when a blood vessel in the brain bursts. When that occurs, part of the brain is starved of its needed supply of blood and oxygen, so brain cells die. Today in the United States alone we know:

  • Every 40 seconds someone in the US has a stroke
  • Every 4 minutes someone in the US dies from a stroke
  • Stroke is the leading cause of long-term disability

Time to treatment is essential for patients, as the longer blood flow is shut off to the brain the more damage occurs. Current treatments for ischemic stroke, the most common type of stroke, are often dangerous and invasive, with the most common being emergency surgery.  

  • Incidence of stroke is increasing internationally, and claimed over 6.2 million lives in 2016. By 2030 its estimated that almost 4 percent of U.S. adults — nearly one in 25 — will have a stroke. This translates into an additional 3.4 million people with stroke in 2030. And, costs to treat stroke may increase from $71.55 billion in 2010 to $183.13 billion in 2030. *

Our lead candidate for ischemic stroke, AB126, is advancing rapidly in preclinical studies and will enter first-in-human studies in 2019. To learn more about AB126, visit the Programs page.

*Statistics are from the American Heart Association